What is the feasibility of cutting the big plates by hand?

What is the feasibility of cutting the big plates by hand? My time frame for doing the cut it forward thing probably won’t work as I am looking to build a machine over the next year. I do cut panels for airplanes by hand, maybe if I do most of the work in a drill press, I could be OK, but probably not enough precision to align the roller holes.

Getting cut on a laser or water jet would be my recommendation