When I started 3D printing, I followed common practice of printing only in the first quadrant — with the origin at the lower left looking down at the build plate. Some time later, I read advice on Mark Rehorst’s blog suggesting that putting the origin at the center of the build plate would make gcode portable between generally similar printers, and thought it made sense but didn’t want to invalidate all my existing gcode files.
But now I just put a spring steel PEI-surfaced bed on one printer, and after tearing apart my original printer apart for spare parts, I built a new printer from scratch that just started printing today. So I set both printers to have the origin at the center so that gcode will be generally portable between the printers, at least if it’s not running too fast for the slower printer.
I hope I like this.